More Peptides for Beauty, Biohacking & Longevity (Part 3)

In the final part of our peptide series, we’re exploring the more experimental and cutting-edge peptides being used by biohackers, longevity researchers, and advanced anti-aging clinics. These are not for beginners — but if you’re already familiar with foundational peptides, this is the next frontier.

1. Melanotan I & II – Tanning & Libido Peptides

Melanotan peptides stimulate melanin production in the skin, promoting a natural tan. Melanotan II also activates receptors involved in libido and appetite suppression.

• Benefits:
– MT-I: Skin tanning, photoprotection (used for EPP)
– MT-II: Tanning, libido boost, mild fat loss effects
• Typical Dosage: 250–500 mcg daily; cycle after reaching desired skin tone
• Notes: MT-II may cause nausea and mole darkening; MT-I is FDA-approved for rare sun sensitivity conditions

2. MOTS-c – The Mitochondrial Peptide

MOTS-c is a peptide derived from mitochondria that plays a key role in regulating metabolism, improving insulin sensitivity, and supporting weight loss.

• Benefits: Increases energy, improves fat metabolism, reduces insulin resistance
• Typical Dosage: 5–15 mg 2–3x per week
• Notes: Still in research phase but gaining popularity in biohacking circles

3. FOXO4-DRI – The Senolytic Peptide

FOXO4-DRI is an experimental peptide that selectively targets and removes senescent cells — the so-called “zombie cells” that accumulate with age and contribute to inflammation and aging.

• Benefits: Potential anti-aging, improved tissue regeneration
• Typical Dosage: Experimental – early animal studies use weekly dosing for 4–8 weeks
• Notes: Use only under close medical supervision, as research is ongoing

4. Humanin – Brain & Cellular Protection

Humanin is a mitochondrial-derived peptide shown to protect neurons, regulate apoptosis, and potentially reduce Alzheimer’s risk.

• Benefits: Cognitive support, neuroprotection, anti-aging
• Typical Dosage: 5–10 mg 2–3x per week (based on early studies)
• Notes: Still under investigation for longevity applications

5. Thymosin Alpha-1 – Immune Optimization

Thymosin Alpha-1 (Tα1) is used to enhance immune function, modulate inflammation, and support recovery from infections and autoimmune conditions.

• Benefits: Boosts immune response, supports cancer therapy and chronic illness recovery
• Typical Dosage: 1.6 mg 2–3x weekly
• Notes: Well-studied, especially in chronic infections like hepatitis

Final Thoughts:

These peptides represent the cutting edge of longevity and bio-enhancement. Many are still considered experimental, so if you’re curious, work with a practitioner who’s experienced in advanced peptide therapy.

This concludes our 3-part peptide blog series — giving you a full-spectrum understanding from basics to breakthroughs. If you found this series helpful, explore our directory or reach out to find a peptide-literate functional doctor in your area.

Disclaimer:

This blog is for informational and educational purposes only. Peptides are powerful therapeutic tools and should only be used under the guidance of a qualified medical professional — preferably a functional medicine doctor experienced in peptide protocols. Always consult a healthcare provider before starting any new treatment.

References:

– Baar M.P. et al. “Targeted apoptosis of senescent cells.” Cell, 2017.
– Lee C. et al. “MOTS-c promotes metabolic homeostasis.” Cell Metabolism, 2015.
– Kleinman H.K. “Thymosin Alpha-1 and immune regulation.” Advances in Pharmacology, 2022.
– Humanin and Alzheimer’s prevention: Nature Reviews Neuroscience, 2021.
– Wikipedia & PubMed articles on Melanotan I & II safety and clinical use

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