In this second part of our peptide series, we’re diving into peptides that support your body’s natural hormone production, metabolism, and fat loss. These peptides don’t replace your hormones — they work with your body to optimize what you already have. Ideal for women over 50 who are looking for natural ways to maintain strength, energy, and a healthy weight.
1. CJC-1295 – The Growth Hormone Booster
CJC-1295 is a growth hormone-releasing hormone (GHRH) analog that stimulates your body’s natural production of growth hormone. It helps with fat burning, muscle growth, and cellular repair.
• Benefits: Increases GH and IGF-1, enhances fat loss, boosts energy and recovery
• Typical Dosage: 100–200 mcg daily or 5x/week, often combined with Ipamorelin
• Notes: Best used consistently for 8–12 weeks
2. Ipamorelin – Gentle GH Release
Ipamorelin is a growth hormone secretagogue that works by gently encouraging the pituitary gland to release GH. It’s known for being one of the cleanest and safest peptides with minimal side effects.
• Benefits: Enhances recovery, promotes fat burning, supports better sleep
• Typical Dosage: 200–300 mcg daily or 5x/week
• Notes: Often paired with CJC-1295 for synergy
3. Tesamorelin – Belly Fat Reduction & Brain Health
Tesamorelin is FDA-approved for reducing visceral fat (deep belly fat) in HIV-associated lipodystrophy, but it’s also being used off-label for cognitive enhancement and age-related fat reduction.
• Benefits: Targets belly fat, may support memory and brain health
• Typical Dosage: 2 mg daily
• Notes: Administered subcutaneously, ideally under a functional medicine doctor’s supervision
4. GLP-1 Agonists (Semaglutide, Tirzepatide)
GLP-1 peptides like Semaglutide (Ozempic, Wegovy) and Tirzepatide (Mounjaro) have become well known for supporting weight loss and metabolic health. Originally developed for diabetes, these peptides also help regulate appetite and blood sugar.
• Benefits: Weight loss, appetite control, blood sugar regulation
• Typical Dosage: Semaglutide starts at 0.25 mg weekly, Tirzepatide starts at 2.5 mg weekly
• Notes: Should be introduced slowly to minimize nausea; long half-life means weekly injections
Final Thoughts:
Hormone-supporting peptides offer a promising path for midlife wellness. They don’t override your system — they support it. If you’re struggling with belly fat, low energy, or metabolic slowdown, working with a qualified practitioner to explore these peptides could be life-changing.
In Part 3, we’ll look at advanced, aesthetic, and biohacking peptides like Melanotan, FOXO4-DRI, and Humanin.
Disclaimer:
This blog is for informational and educational purposes only. Peptides are powerful therapeutic tools and should only be used under the guidance of a qualified medical professional — preferably a functional medicine doctor experienced in peptide protocols. Always consult a healthcare provider before starting any new treatment.
Disclaimer NOTE: I’m sharing this based on research and personal experience. Please consult with a functional medicine doctor or qualified health professional before using peptides, especially if you’re considering injections or hormone-related compounds.
References:
– Schally A.V. Growth hormone-releasing hormone analogs. Nat Rev Endocrinol, 2025.
– Drucker D.J. GLP-1 mechanisms in weight loss. Nat Rev Cardiol, 2023.
– Clinical studies on Tesamorelin and visceral fat: NEJM, 2010.
– Patient-reported outcomes from Reddit GLP-1 and peptide communities.